7,8-Dihydroxyflavone Powder

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7,8 – Dihydroxyflavone, also referred to as 7,8 -DHF, is a flavonoid derived from plants with important nootropic effects. It has recently been the subject of much research because of its cognitive and motor enhancing effects on the brain. It has the chemical formula C15H10O4 and a molecular weight of 254.24g/mol.

7,8- Dihydroxyflavone Benefits and Uses

7,8-DHF is believed to have important health benefits on the brain. It is thought to activate the ‘tropomyosin-related kinase B (TrkB)’, the usual target receptor of ‘Brain Derived Neurotropic Factor’ (BDNF). BDNF is a peptide and essential contributor to brain function because it promotes neuronal and synaptic growth. An adequate level of the BDNF peptide is crucial to prevent neuro-degeneration.

However, because BDNF does not effectively cross the blood-brain barrier, it has poor absorption in the brain. Anecdotally, 7,8 – DHF may mimic the effects of BDNF. It is thought to be a TrkB agonist as it binds to the Trkb receptor in a similar way as BDNF. Studies have shown it may have similar neuroprotective effects on the brain as BDNF because of its ability to cross the blood-brain barrier. These include improved memory, reduced stress, and repair of damaged neurons.

Furthermore, 7, 8-DHF may also exert antioxidant activity on the body by replenishing glutathione, as well as act as an antioxidant and support a healthy circulatory system. That being said, these findings stem from animal studies and have not yet been proven on human models.

7, 8-DHF supplements are also known by a few different names, including:

  • 38183-03-8
  • 7, 8 – Dihydroxyflavone
  • 7,8-dihydroxy-2-phenyl-4H-chromen-4-one
  • PubChem9845
  • 7, 8-Dihydroxyflavone hydrate
  • 7,8- Dihydroxy-flavone
  • 7, 8 – DHF
  • 4H-1-Benzopyran-4-one,7,8-dihydroxy-2-phenyl-
  • 7,8-diOH-Flavone

Scientific Consensus

Currently, there are no human studies on 7,8 – DHF. 7,8 – DHF supplements may cause mild and rare side effects such as dizziness, insomnia and nausea. Due to lack of insufficient data regarding the safety of this product for pregnant or breastfeeding women, it should be avoided by these groups.

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The statements on this page have not been evaluated by the FDA. The products on this page are not intended to diagnose, treat, cure, or prevent any disease.

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As a dietary supplement, take 1 serving up to 2 times per day. Please start with the lowest suggested single serving quantity to assess response.

Supplement Facts

Serving size: 40mg
Servings per container:
Amount per serving: % DV


LiftMode offers a variety of unit sizes of 7,8-Dihydroxyflavone Powder, including a a 1g unit, a 2g unit, a 5g unit and a 10g unit. Our 7,8-Dihydroxyflavone Powder is of the highest quality.
Store securely in a dry cool location away from direct sunlight. Keep out of reach of children and pets. Do not take this or any other supplement, and instead consult doctor about use, if you are under the age of 18, pregnant or breastfeeding, taking prescription or OTC / nonprescription drugs, or if you have any known or suspected medical conditions. Do not use if product safety seal was damaged or missing upon receipt.
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Scientifically Tailored Ingredients

7,8-DHF (7,8-Dihydroxyflavone) is a naturally occurring flavonoid with possible cognition-enhancing properties. Its recent discovery has spurred research into its unique properties.

By enhancing TrkB expression, 7,8-DHF may help to increase the rate new synapses are formed, thus enhancing learning. Some researchers hypothesize that 7,8-DHF does not bind TrkB directly, but instead acts on an unknown pathway that results in the same end result–increased TrkB activity. 7,8-DHF is believed to have a similar degree of neurogenic activities as BDNF.

On top of its effects on neurogenesis, 7,8-DHF is also neuroprotective. It has antioxidant properties in the brain that are independent of its TrkB activity. While these mechanisms are not understood, it is believed to activate the Akt/PKB pathway.

* Supports Healthy Memory and Focus
* May Promote Adult Neurogenesis
* Neuroprotective and Antioxidant

National Center for Biotechnology Information (2020). PubChem Compound Summary for CID 1880, 7,8-Dihydroxyflavone. Retrieved December 12, 2020 from
García-Díaz Barriga G, Giralt A, Anglada-Huguet M, Gaja-Capdevila N, Orlandi JG, Soriano J, Canals JM, Alberch J. 7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington’s disease mouse model through specific activation of the PLCγ1 pathway. Hum Mol Genet. 2017 Aug 15;26(16):3144-3160. doi: 10.1093/hmg/ddx198. PMID: 28541476.
Wang B, Wu N, Liang F, Zhang S, Ni W, Cao Y, Xia D, Xi H. 7,8-dihydroxyflavone, a small-molecule tropomyosin-related kinase B (TrkB) agonist, attenuates cerebral ischemia and reperfusion injury in rats. J Mol Histol. 2014 Apr;45(2):129-40. doi: 10.1007/s10735-013-9539-y. Epub 2013 Sep 13. PMID: 24045895.
Huai R, Han X, Wang B, Li C, Niu Y, Li R, Qu Z. Vasorelaxing and antihypertensive effects of 7,8-dihydroxyflavone. Am J Hypertens. 2014 May;27(5):750-60. doi: 10.1093/ajh/hpt220. Epub 2013 Dec 6. PMID: 24317273.