Palmitoylethanolamide Powder

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Palmitoylethanolamide (PEA) is an endogenous fatty acid produced naturally in cell membranes. PEA supplement is being used for its important neuroprotective and antioxidant properties. It has a molar mass of 299.5g/mol and the chemical formula C18H37NO2.

Palmitoylethanolamide (PEA) Benefits and Uses

Palmitoylethanolamide is an endogenous fatty acid amide, a type of endocannabinoid compound formed in the brain from phospholipids. Chemically, it is the ethanolamide of palmitic (hexadecanoic) acid and is also known as an N-acylethanolamide,

PEA is a signaling molecule that plays an important role in modulating the nervous system. It has antioxidant and immune-supporting effects.. PEA may also have neurorprotective properties.

Palmitoylethanolamide supplements are also known by a few different names, including:

  • N-palmitoyl ethanolamine
  • Hydroxyethylpalmitamide
  • Anandamide (16:0)
  • 544-31-0
  • Palmitic acid monoethanolamide
  • Palmidrolum
  • Impulsin
  • N-(2-Hydroxyethyl)hexadecanamide
  • Palmidrol

Scientific Consensus

Resposible usage of Palmitoylethanolamide at the recommended serving suggestion is thought to be safe.

Keep out of reach of children. Do not take this supplement if you are under the age of 18, pregnant or nursing, have a known or suspected medical condition, or if you are taking any prescription and/or OTC medications.

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The statements on this page have not been evaluated by the FDA. The products on this page are not intended to diagnose, treat, cure, or prevent any disease.

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Serving size is 400 mg. As a dietary supplement, take 1 serving up to 2 times per day. Please start with the lowest suggested single-serving quantity to assess response.

Supplement Facts

Serving size: 400mg
Servings per container:
Amount per serving: % DV


400 mg
LiftMode offers a variety of unit sizes of HPLC-tested Palmitoylethanolamide Powder, including a a 20g unit, a 100g unit, a 200g unit, a 50g unit and a 500g unit. Our Palmitoylethanolamide Powder is of the highest quality.
Store securely in a dry cool location away from direct sunlight. Keep out of reach of children and pets. Do not take this or any other supplement, and instead consult doctor about use, if you are under the age of 18, pregnant or breastfeeding, taking prescription or OTC / nonprescription drugs, or if you have any known or suspected medical conditions. Do not use if product safety seal was damaged or missing upon receipt.
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Scientifically Tailored Ingredients

Found naturally in foods such as egg yolks, PEA is an endogenous fatty-acid amide with demonstrated benefits in easing everyday aches and pains. It works by binding to peroxisome proliferator-activated receptors in the cell nucleus, where it exerts numerous physiological effects:

– Helps Reduce Everyday Aches and Pains
– Well Tolerated, Endocannabinoid-like Molecule
– May help to ease joint discomfort
– Neuroprotective

Passavanti, M.B., Alfieri, A., Pace, M.C. et al. (2019). Clinical applications of palmitoylethanolamide in pain management: protocol for a scoping review. Systematic Reviews, 8, 9.

Lu, H. C., & Mackie, K. (2016). An Introduction to the Endogenous Cannabinoid System. Biological Psychiatry, 79(7), 516–525.

National Center for Biotechnology Information (2021). PubChem Compound Summary for CID 4671, Palmitoylethanolamide. (database entry). Bethesda, MD: US NLM-National Center for Biotechnology Information (NCBI).Retrieved June 17, 2021 from

Keppel Hesselink, J. M., & Kopsky, D. J. (2015). Palmitoylethanolamide, a neutraceutical, in nerve compression syndromes: efficacy and safety in sciatic pain and carpal tunnel syndrome. Journal of pain research, 8, 729–734.