Oleamide Powder

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Oleamide (cis-9,10-octadecenoamide) is a derivative of oleic acid and is a functional fatty acid in the human brain. It is biosynthesized from oleic acid and ammonia and metabolized by FAAH. It has a molecular weight of 281.484 g/mol and the chemical formula C18H35NO.

Oleamide Benefits and Uses

Oleamide (also known as cis-9,10-octadecenoamide) is biosynthesized from oleic acid and ammonia in the human brain and the brains of most mammals. It is known to help regulate sleep patterns and to interact with the GABAergic system. It is also remarkably efficient at augmenting the signalling of the serotonergic system and is able to do so even at very low concentrations (as low as 1nM).

In mammals, it accumulates in the brain and nervous system during sleep deprivation. Anecdotally, it may have similar effects to other relaxing supplements. However, the significance of its benefits will only be fully understood once further research becomes available.

Oleamide supplements are also known by a few different names, including:

  • (Z)-Octadec-9-enamide
  • Oleylamide
  • 9-Octadecenamide
  • (Z)-9-Octadecenamide
  • 9,10-Octadecenoamide
  • Oleic acid amide
  • Cis-9,10-octadecenoamide
  • Oleyl Amide
  • Cerebrodiene

Scientific Consensus

Oleamide is a relatively new supplement and further research is required to fully understand the significance of its benefits, uses, and side effects. Using this supplement at the recommended serving size is likely safe for most adults.

DO NOT EXCEED THE RECOMMENDED SERVING SIZE. Use with caution. Do not use if pregnant or breastfeeding.

Warning: Oleamide may interact with a variety of medications. Please make sure that you speak to your doctor before using this supplement if you are taking any medication.

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The statements on this page have not been evaluated by the FDA. The products on this page are not intended to diagnose, treat, cure, or prevent any disease.
November 1, 2023
Mano Appapillai
Oleamide Powder

Need more time to evaluate. Packaging, delivery speed etc excellent

October 8, 2023
Isaac Livingstone
Oleamide Powder

Effective in the first night of administration to my sleep stack.

June 4, 2023
Michael Deja
Oleamide Powder

Hugh quality product. At a good price, clean, and effective!!

April 12, 2023
Michele Tilton
Oleamide Powder

I love this product it helps me to get to sleep every night.

Serving size is 200 mg. As a dietary supplement, take 1-4 servings, either 1 hour prior to desired sleep, up to 2 times per day. Please start with the lowest suggested single serving quantity to assess response.

Supplement Facts

Serving size: 200mg
Servings per container:
Amount per serving: % DV

Oleic acid amide (derived from vegetable sources) [std. to ≥25% Amides (Oleamide 50mg)]

200 mg
LiftMode offers a variety of unit sizes of HPLC-tested Oleamide Powder, including a a 500g unit, a 200g unit, a 100g unit, a 1000g unit and a 50g unit. Our Oleamide Powder is of the highest quality.
Store securely in a dry cool location away from direct sunlight. Keep out of reach of children and pets. Do not take this or any other supplement, and instead consult doctor about use, if you are under the age of 18, pregnant or breastfeeding, taking prescription or OTC / nonprescription drugs, or if you have any known or suspected medical conditions. Do not use if product safety seal was damaged or missing upon receipt.
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Free from additives and fillers
Gluten Free
HPLC Lab tested
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Science backed

Scientifically Tailored Ingredients

Oleamide is a naturally occurring derivative of oleic acid (found in olive oil) which has calming, mood lifting, and sleep and appetite promoting effects.

– Calming & Stress Reducing
– Uplifts Mood
– Promotes Healthy Sleep

Mueller, G.P., Driscoll, W.J. (2009). Biosynthesis of oleamide. Vitam Horm. 81:55-78.

Basile, A.S., Hanus, L., Mendelson, W.B. (1999). Characterization of the hypnotic properties of oleamide. Neuroreport. 10(5):947-51.

Coyne, L., Lees, G., Nicholson, R.A., Zheng, J., Neufield, K.D. (2002). The sleep hormone oleamide modulates inhibitory ionotropic receptors in mammalian CNS in vitro. British Journal of Pharmacology. 35(8):1977-1987.

Huidobro-Toro, J.P., Harris, R.A. (1996). Brain lipids that induce sleep are novel modulators of 5-hydroxytrypamine receptors. Proc Natl Acad Sci U S A. 23;93(15):8078-82.

Boger, D.L., Henriksen, S.J., Cravatt, B.F. (1998). Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules. Curr Pharm Des. 4(4):303-14.