L-Tetrahydropalmatine (L-THP) Powder

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L-THP (also known as Corydalis Extract or Yan Hu Suo) is a potent berberine-type heterocyclic alkaloid. It has been used in research for its potential as a dopamine receptor antagonist. It has a molecular mass of 355.428 g/mol and the chemical formula C21H25NO4.

L-Tetrahydropalmatine (Corydalis Extract) Benefits and Uses

Corydalis yanhusuo (Yan Hu Suo) is a traditional Chinese herbal medicine that has been used in traditional Chinese herbal medicine for hundreds of years and contains the potent berberine-type compound, Levo-Tetrahydropalmatine (L-THP).

While it has been used in several studies with human participants, more research is required to fully understand the significance of this compounds benefits and side effects.

L-THP supplements are also known by a few different names, including:

  • Tetrahydropalmatine
  • Yanhusou
  • Yan Hu Suo
  • Corydalis extract
  • L-THP
  • (-)-Corydalis
  • (S)-(-)-tetrahydropalmatine
  • 483-14-7
  • Cordyalis extract

Scientific Consensus:

Supplementing with this probably safe at the recommended serving size, but large servings can be dangerous to your health. There is a need for further research into the health effects of long-term supplementation and the use of larger servings. L-THP has the potential to interact with some medications, and caution should be used.

DO NOT EXCEED THE RECOMMENDED SERVING SIZE. Use with caution. Do not use if pregnant or breastfeeding.

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The statements on this page have not been evaluated by the FDA. The products on this page are not intended to diagnose, treat, cure, or prevent any disease.
November 21, 2023
Mike B.
L-Tetrahydropalmatine (L-THP) Powder

The product is superior, the company is knowledgeable, friendly, and professional. Ordering was a breeze and shipping was efficient. My order was promptly processed and shipped, and arrived much earlier than expected! If anyone has doubts about this company, dismiss them. The product is top shelf. I've used other vendors in the past, but these guys consistently rise to the top. Very highly recommended. Great job LiftMode team!

November 3, 2023
L-Tetrahydropalmatine (L-THP) Powder

This really helps with sleep without the hangover the next morning, if you follow the suggested amount!

September 30, 2023
Jon James
L-Tetrahydropalmatine (L-THP) Powder

Very strong!! Following dosing recommendations is advisable and produces an effect.

August 26, 2023
Bryce C.
L-Tetrahydropalmatine (L-THP) Powder

Does what uts supposed to..

Serving size is 30 mg. As a dietary supplement, take 1-4 servings, 1 hour prior to sleep. Please start with the lowest suggested single serving quantity to assess response.

Supplement Facts

Serving size: 30mg
Servings per container:
Amount per serving: % DV

L-Tetrahydropalmatine 98%[std. to 98% L-Tetrahydropalmatine (30mg)]

LiftMode offers a variety of unit sizes of HPLC-tested L-Tetrahydropalmatine (L-THP) Powder, including a a 10g unit and a 2g unit. Our L-Tetrahydropalmatine (L-THP) Powder is of the highest quality.
Store securely in a dry cool location away from direct sunlight. Keep out of reach of children and pets. Do not take this or any other supplement, and instead consult doctor about use, if you are under the age of 18, pregnant or breastfeeding, taking prescription or OTC / nonprescription drugs, or if you have any known or suspected medical conditions. Do not use if product safety seal was damaged or missing upon receipt.
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Scientifically Tailored Ingredients

L-Tetrahydropalmatine (L-THP) is a plant alkaloid used as an ingredient in dietary supplement products. It is said to support healthy sleep.

L-Tetrahydropalmatine (L-THP) is an active ingredient of Corydalis yanhusuo, one of the 50 fundamental herbs in traditional Chinese herbology.

– Promotes Restful Sleep
– Powerful Antioxidant
– Calming and Relaxing

Horowitz, R.S., et al. The clinical spectrum of Jin Bu Huan toxicity. Arch Intern Med. 1996 Apr 22;156(8):899-903.

Kelly, D., et al., Treatment of… With L-tetrahydropalmatine (l-THP): a Novel Dopamine Antagonist With Anti-inflammatory and Antiprotozoal Activity. Clinical Trials Indicator NCT02118610. The University of Maryland, Stanley Medical Research Institute, 2014-2017.

Oh, Y.C., et al., Tetrahydropalmatine inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated THP-1 cells. J Med Food. 2010 Oct;13(5):1125-32. doi: 10.1089/jmf.2009.1388.

Tetrahydropalmatine. (2019). PubChem, Compound Summary for CID 72301, Open Chemistry Database, US National Library of Medicine, available online at