BaiCalm (Baicalein Complex) Sample

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Serenity without sedation.

A research-driven supplement to soften life’s edges, tame tension, and promote meditative clarity: BaiCalm is calm you can feel.

Containing an HPLC-verified, synergized stack of bioactive, GABAergic, tranquility-promoting plant extracts, Baicalm is an ‘Advanced Calm Complex’: masterfully formulated for superior bioavailability, delivering noticeable calm, and a heightened sense of well-being.

How it Works: Gabaergic compounds and nervous system regulation

The inhibitory signaling of GABA (γ-Aminobutyric acid) via binding and activation of GABA receptors is a key messaging system a healthy central nervous system utilizes to reduce neuronal excitability and regulate emotions such as fear, panic, or intense stress. Developed via our three pillar methodology, the BaiCalm formula starts with a research-driven, synergized stack of potent, natural GABAergic compounds.

Pillar 1: GABAergic Synergy – 3 Calming Plant Extracts

> Scutellaria Baicalensis Extract [Std. to ≥98% Baicalein]

Baicalein (5,6,7-trihydroxyflavone) is a potent flavonoid from Skullcap (S. Baicalensis), with a long history of use in Traditional Chinese Medicine. 2-3x more bioavailable than baicalin, a wealth of studies have asserted strong GABAergic activity of baicalein via modulation of the brain’s benzodiazepine site of the GABA-A receptors. This subtle but noticeable downshift of neuronal response to ‘fight or flight’ supports serenity without sedation – so you can wind down without tuning out.

Not only a long-term LiftMode favorite for calming nerves, baicalein is a potent antioxidant and has been extensively researched for a myriad of other ways in which it can promote wellbeing – including activities as a neuroprotective, a promoter of circulatory health, and supporter of an upbeat and resilient mood – each enabled by gentle downregulation of cytokine signaling throughout the brain and body.

> Magnolia Bark Extract [Std. to ≥95% Honokiol & Magnolol]

Baicalm’s Magnolia Bark Extract (M. Officianalis), favored in TCM as a soothing relaxant, contains a ≥95% concentration of powerful bioactive neolignan constituents magnolol and honokiol. Synergizing with baicalein, these neuroprotective compounds have both been shown to enhance GABAergic neurotransmission, binding to and positively modulating GABA-A receptors.

Research continues to explore other positive effects of magnolol and honokiol, beyond their impact on mood-regulating serotonin receptors and stress-related catecholamines. Magnolia bark extract continues to be a popular natural remedy for not only calming, but also as a supplement to enhance mood, reduce stress and support an overall sense of reassurance and wellbeing.

At LiftMode, we call it “the BaiCalm glow”.

> Sinomenium Accutum Extract [Std. to ≥98% Sinomenine HCL]

Extracts of the plant Sinomenium acutum have a long history of use in Japan, China and Korea as traditional medicine for stabilizing mood, easing discomfort and soothing various aches and pains. Only recently have researchers begun to explore this natural extract’s primary alkaloid (Sinomenine) and its relaxing and relieving properties, with animal trial results attributing these effects in part due to GABAergic system modulation via interaction with GABA-A receptors.

While the use of sinomenine in higher doses has been explored as a potential sleep aid, Our Baicalm serving is formulated to deliver the perfect amount for daily tranquility, stress reduction, and comfort.

Pillar 2: Wakeful Rest – Meditative Focus

> L-Theanine [Std. to ≥99% pure]

Present in small amounts in tea and mushrooms, L-theanine is credited for the sense of relaxed contentment and clarity of thought after drinking green tea.

In recent years, studies have continued to evidence the calm-promoting and focus-inducing properties of this phytochemical. Research using electroencephalograph (EEG) found that consumption of L-theanine significantly increases alpha wave brain activity, a wave frequency observed in the brain during meditation and in states of wakeful rest. One serving of BaiCalm contains the L-Theanine content of about 12 strong cups of green tea.

Pillar 3: Superior Bioavailability – An Advanced Calm Complex

> Curcumin [Standardized to ≥95% curcuminoid]
> Black Pepper Fruit Extract [≥95% Piperine]

Our R&D team set out with a goal to deliver the most effective baicalein complex on the market.

Key in this effort was the addition of synergistic ingredients to enhance its GABAergic properties, but we also needed to address some longstanding challenges with standalone baicalein extracts: delayed onset, and limited absorption due to low GI solubility and stability.

After a long developmental process, and the carefully balanced addition of curcumin and piperine, our BaiCalm complex contains the perfect delivery system, painstakingly formulated for ultimate bioavailability. Piperine is well known for its positive impact on metabolism, and its ability to significantly improve the absorption and uptake of many dietary supplements. In the specific case of curcumin, piperine increases bioavailability by up to 2000%. When paired with baicalein, research found curcumin to be even superior to piperine in inhibiting glucuronidation in the lower intestine, resulting in superior baicalein absorption.

It is the effect of this three-step synergy (Piperine > Curcumin > Baicalein) we call our “Advanced Calm Complex”.

More than just an absorption aid, curcumin is also a potent antioxidant, neuroprotective, and a safe daily supplement for a myriad of health benefits. With a low molecular weight enabling passage through the blood-brain barrier, curcumin is capable of interacting with neurotransmitters such as serotonin, making it the subject of extensive research into its potential as a daily supplement to support calm and brighten one’s mood.

A safe natural polyphenol extracted from turmeric root, curcumin maximizes synergy, and is the finishing phytochemical touch to enhance relaxation and promote a palpable sense of well-being

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The statements on this page have not been evaluated by the FDA. The products on this page are not intended to diagnose, treat, cure, or prevent any disease.
January 5, 2024
Ryan Gibbs
BaiCalm (Baicalein Complex) Sample

Amazing compound, doesn't seem to build tolerance.

DAILY SUPPORT: 1-2 capsules, up to two times per day. ACUTE USE: 3 to 4 capsules as needed, up to two times per day. Please start with the lowest dose to assess response. Can be taken with or without food (please be advised - effects may be more pronounced on an empty stomach).

Supplement Facts

Serving size: 2 capsules
Servings per container:
Amount per serving: % DV

Scutellaria Baicalensis Extract [std. ≥98% Baicalein]


Magnolia Bark Extract [Std. to ≥95% Honokiol & Magnolol]


L-Theanine [Std. to ≥99% pure]


Curcumin [Standardized to ≥95% curcuminoid]


Sinomenium Acutum Stem Extract [Std. to ≥98% Sinomenine HCl]


Black Pepper Fruit Extract [≥95% Piperine]

A comprehensive modulator of GABA receptor sites, BaiCalm comes without the risk of dependence, memory issues or excessive sleepiness associated with other widely used substances that act similarly on the central nervous system. Ingredients in BaiCalm may amplify the effects of alcohol and sedative, hypnotic or anxiolytic substances and medications - therefore it is very important to avoid exposure that could result in such combinations. Although BaiCalm has been formulated to support relaxation without excess drowsiness, results may vary based on the individual. Until you are confident in your individual response to BaiCalm, it may not be safe to consume while operating heavy machinery or driving. Store securely in a dry cool location away from direct sunlight. Keep out of reach of children and pets. Do not take this or any other supplement, and instead consult doctor about use, if you are under the age of 18, pregnant or breastfeeding, taking prescription or OTC / nonprescription drugs, or if you have any known or suspected medical conditions. DO NOT take BaiCalm before surgery as it may affect the drugs used for sedation. Always consult your physician if you have any underlying medical issues. Do not use if product safety seal was damaged or missing upon receipt. The statements on this page have not been evaluated by the FDA. The products on this page are not intended to diagnose, treat, cure, or prevent any disease.
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Free from additives and fillers
Gluten Free
HPLC Lab tested
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Science backed

Scientifically Tailored Ingredients

Baicalein is the primary active component from the Blue Skullcap plant (also known as Baikal Skullcap). This powerful phytochemical is known to act on GABA receptors to promote relaxation and relieve stress. Baicalein also acts as a strong antioxidant supplement and helps to promote a healthy circulatory system.

• Calming and Stress-Reducing
• Antioxidant and Immune Support
• 5 – 10x Bioavailability Compared to Baicalin

Magnolia Bark Extract is an ingredient used in traditional medicine and dietary supplements, containing the beneficial ingredients Honokiol and Magnolol.

In addition to their calming properties, Honokiol and Magnolol have numerous protective health benefits based on their antioxidant and brain-health supporting effects.

– Calming & Relaxing
– Antioxidant & Immune Support
– Promotes Brain Health

L-Theanine is a naturally occurring nutrient found in tea, and is used as an ingredient in dietary supplement products.

Studies suggest that L-Theanine may help reduce mental and physical stress, improve cognition and boost mood. L-Theanine is unique in supporting a calm mood while at the same time enhancing a sense of clarity and focus.

– Reduces Stress
– Boosts Cognition
– Calming

Curcuma longa (Turmeric) is a flowering plant which is a member of the ginger family. Turmeric powder is arguably one of the most effective and beneficial naturally occurring supplements available. The active compounds within Turmeric (which give it all of its well-known healthful effects) are called curcuminoids.

The most powerful and effective curcuminoid is Curcumin, an extremely powerful antioxidant. Curcumin has also been found to boost brain health function through its effective neuroprotective properties.

– Supports a Positive Mood
– Promotes Healthy Circulatory System
– Powerful Antioxidant

Sinomenine is the active compound in the roots of the *Sinomenium acutum* plant. As a herbal extract, Sinomenium acutum has been used traditionally for its neuroprotective properties. Research suggests it assists in increasing the influx of chloride into the cells of the hypothalamus – a small part of the brain that plays an important role in energy maintenance and in stress control.

– Mood Lifting
– Potent Neuroprotective Properties
– Supports Immune Function

Piperine is an alkaloid extracted from black pepper and is typically used for its ability to inhibit the process of glucuronidation. This allows for significantly increased absorption of many types of dietary supplements.

– Antioxidant Effects
– Slows the Degradation of Polyphenols
– Improves Ingredient Bioavailability

Yoo JH, Ha TW, Hong JT, Oh KW. Sinomenine, an Alkaloid Derived from Sinomenium acutum Potentiates Pentobarbital-Induced Sleep Behaviors and Non-Rapid Eye Movement (NREM) Sleep in Rodents. Biomol Ther (Seoul). 2017 Nov 1;25(6):586-592. doi: 10.4062/biomolther.2017.157. PMID: 29081090; PMCID: PMC5685427.

Bochoráková, H., Paulová, H., Slanina, J., Musil, P., Táborská, E. (2003). Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Phytother Res, 17(6):640-4.

Wang, H., Hui, K.M., Chen, Y., Xu, S., Wong, J.T., Xue, H. (2002). Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to the benzodiazepine site of GABA(A) receptor complex. Planta Med, 68(12):1059-62.

Fong, Sophia & Li, Chen & Wo, SK & Wang, Shu & Zhou, Limin & Zhang, Li & Lin, Ge & Zuo, Zhong. (2011). In vitro and in situ evaluation of herb-drug interactions during intestinal metabolism and absorption of Baicalein. Journal of ethnopharmacology. 141. 742-53. 10.1016/j.jep.2011.08.042.

Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8. PMID: 18296328.

Hewlings SJ, Kalman DS. Curcumin: A Review of Its Effects on Human Health. Foods. 2017 Oct 22;6(10):92. doi: 10.3390/foods6100092. PMID: 29065496; PMCID: PMC5664031.

Kulkarni SK, Dhir A. An overview of curcumin in neurological disorders. Indian J Pharm Sci. 2010 Mar;72(2):149-54. doi: 10.4103/0250-474X.65012. PMID: 20838516; PMCID: PMC2929771.