Agmatine Sulfate Powder

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Agmatine is a newly understood neurotransmitter that is produced from L-Arginine. It is synthesized in the brain and stored in synaptic vessels for use in receptor signaling pathways. Agmatine has the chemical formula C5H14N4 and a molecular mass of 130.195 g/mol.

Agmatine Sulfate Benefits and Uses

Agmatine Sulfate is an amino acid derivative that has recently been discovered to act as a neurotransmitter. It has been used in research for analgesic and neuroprotective effects. It works primarily as an NMDA receptor antagonist, an alpha-2-adrenergic receptor activator, and a serotonin signal enhancer. It also helps regulate nitric oxide production and may block Ca2+ and K+ channels.

Agmatine Sulfate is known by a number of alternative names, including:

  • 1-(4-Aminobutyl)guanidine
  • Agmatin
  • Agmatine Sulfate

Scientific Consensus

Agmatine is a naturally-occurring chemical found in plant species, animals, and humans. It is made from L-arginine. Agmatine sulfate is considered possibly safe for use by most people at the recommended serving size.

There is still a need for further research to properly understand the significance of its benefits and adverse effects. Some people have reported experiencing diarrhoea, upset stomach, and nausea.

Warning: There is not enough research about the safety of Agmatine for pregnant and breastfeeding women. Do not use this supplement if you have any underlying medical conditions – especially people with diabetes, or undergoing surgery.

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The statements on this page have not been evaluated by the FDA. The products on this page are not intended to diagnose, treat, cure, or prevent any disease.
August 22, 2023
Agmatine Sulfate Powder

This is an underrated supplement. Benefits range from good pumps, pain relief, mood boosting . No side effects. I definitely notice when I stop taking.

July 25, 2023
Jena Chanel
Agmatine Sulfate Powder

I have just started using this product a day ago, so still in review

July 24, 2023
Shawn Ross
Agmatine Sulfate Powder

Agmatine Sulfate

April 7, 2023
Christopher Wilson
Agmatine Sulfate Powder

Clean good stuff

As a dietary supplement, take 1-2 servings up to 2 times per day. Please start with the lowest suggested single serving quantity to assess response.

Supplement Facts

Serving size: 600mg
Servings per container:
Amount per serving: % DV

Agmatine Sulphate (1-Amino-4-guanidinobutane sulfate salt)

LiftMode offers a variety of unit sizes of HPLC-tested Agmatine Sulfate Powder, including a a 100g unit, a 200g unit and a 500g unit. Our Agmatine Sulfate Powder is of the highest quality.
Store securely in a dry cool location away from direct sunlight. Keep out of reach of children and pets. Do not take this or any other supplement, and instead consult doctor about use, if you are under the age of 18, pregnant or breastfeeding, taking prescription or OTC / nonprescription drugs, or if you have any known or suspected medical conditions. Do not use if product safety seal was damaged or missing upon receipt.
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Free from additives and fillers
Gluten Free
HPLC Lab tested
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Science backed

Scientifically Tailored Ingredients

Agmatine is a naturally occurring biogenic compound that is derived from an essential amino acid known as L-Arginine. It is used for its benefits on mood and cognition.

Agmatine Sulfate is used as a dietary supplement for its improvements in cognitive health, fitness performance, and intra-workout energy.

* Supports Cognitive Health
* Helps Reduce Stress and Promotes a Positive Mood
* Fitness Performance

Piletz, J. E., Chikkala, D. N., Ernsberger, P. (1995). Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors. J Pharmacol Exp Ther. 272(2):581-7

Wang, C. C., Chio, C. C., Chang, C. H., Kuo, J. R., Chang, C. P. (2010). The beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia. BMC Pharmacol. 10:11

Chang, C. H., Wu, H. T., Cheng, K. C., Lin, H. J., & Cheng, J. T. (2010) Increase of beta-endorphin secretion by agmatine is induced by activation of imidazoline I(2A) receptors in adrenal gland of rats. Neurosci Lett. 2010 Jan 14;468(3):297-9

Keynan, O., Mirovsky, Y., Dekel, S., Gilad, V. H., & Gilad, G. M. (2010). Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled Trial. Pain Med. 11(3):356-68.

uiz-Durántez, E., Ruiz-Ortega, J. A., Pineda, J., & Ugedo, L. (2002). Effect of agmatine on locus coeruleus neuron activity: possible involvement of nitric oxide. Br J Pharmacol. 135(5):1152-8