L-Citrulline (2-Amino-5-(carbamoylamino)pentanoic acid) is an alpha amino acid first extracted from watermelons. It is used in the urea cycle and is taken to boost L-arginine levels and, thus, nitric oxide levels. DL-Malate (malic acid) is a key compound for the synthesis of ATP. L-Citrulline DL-Malate 2:1 is composed of 2 L-Citrulline molecules bound to a single Malic Acid molecule.
L-Citrulline DL-Malate 2:1 Benefits and Uses
L-Citrulline DL-Malate 2:1 is a salt made up of two L-Citrulline molecules bound to one Malic acid molecule. L-Citrulline is a naturally occurring α-amino acid which is a key intermediate in mammalian biochemical and metabolic processes, including the urea cycle. Its nomenclature derives from the Latin name of the watermelon fruit (Citrullus vulgaris), in which its concentration exceeds 2mg per gram of fresh watermelon.
L-Citrulline DL-Malate has been found to increase cellular energy production in a synergistic manner. The ratio of two to one is generally preferred by athletes because it optimizes the mass of L-Citrulline delivered per serving.
L-Citrulline supplements are also known by a few different names, including:
- 2-Amino-5-(carbamoylamino)pentanoic acid
- Citrulline
- Watermelon extract
- L-Citrulina
- AKG
- L-Citrulline Malate
- Citrulline Malate
- 2:1 Citrulline Malate salt
- l-critrulline-dl-malate
Scientific Consensus
Supplementing with L-Citrulline DL-Malate 2:1 is likely safe for adults when taken at the recommended serving size. L-Citrulline is a naturally-occurring amino acid, and as such, side effects are rare and uncommon.
Special Warnings
It is very important to talk to your doctor before using this supplement if you are taking any prescription medication. There is not enough research to support the safety of L-Citrulline supplements for pregnant or breastfeeding women. As such, it is recommended to be avoided.
