DHM (Dihydromyricetin) Powder

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Dihydromyricetin – also known as DHM or Ampelopsin – is a relatively new supplement that occurs in a number of plant species and is used for anti-alcohol and liver-support benefits. Ampelopsin has the chemical formula C15H12O8 and a molecular weight of 320.253 g/mol.

Dihydromyricetin (DHM) Benefits and Uses

Dihydromyricetin (DHM) is taken by mouth for its antioxidant and general health-supporting benefits. It has long been used in Traditional Chinese Medicine (TCM) for a variety of health-supporting effects. More recently, modern scientific investigations have uncovered several modes of action that corroborate DHM’s support of general health including modulation of inflammatory cytokines, modulation of autophagy, modulation of metabolic responses, neuroprotective properties and support of mitochondrial health.
Recent research studies have also revealed several important mechanisms of action relating to DHM’s potential ability to protect the liver and reduce unwanted unpleasant feelings from alcohol use:

  • DHM triggers the production of the enzymes alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH)
  • DHM appears to improve the efficacy of both ADH and ALDH
  • DHM helps to reduce fatty acid accumulation in the liver
  • DHM reduced the expression of inflammation markers in the liver, including IL-1β, NF-κB, and TNF-α.

DHM is known by a number of alternative names including:

  • Ampelopsin
  • (2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
  • Ampelopsis
  • Hovenia dulcis flavonoid extract
  • Dihydromyricetin

Scientific Consensus

DHM is likely safe when taken by mouth. It is taken commonly to help ameliorate unwanted unpleasant feelings from alcohol use and protect the liver. As an oral supplement, the recommended serving size of Dihydromyricetin is 400 mg. Take 1-2 servings up to twice per day.

There is still a need for further research into the significance of DHM’s benefits and adverse effects. Nevertheless, Dihydromycetin appears safe for use at the recommended serving size, with only mild side effects very rarely being reported. There is insufficient research to support the use of DHM (Ampelopsin) supplementation during pregnancy and breastfeeding.

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The statements on this page have not been evaluated by the FDA. The products on this page are not intended to diagnose, treat, cure, or prevent any disease.

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*italic text**italic text*Serving size is 400 mg. As a dietary supplement, take 1 serving up to 2 times per day, with meals or shortly after eating. Please start with the lowest suggested single serving quantity to assess response.

Supplement Facts

Serving size: 400mg
Servings per container:
Amount per serving: % DV


400 mg
LiftMode offers a variety of unit sizes of HPLC-tested DHM (Dihydromyricetin) Powder, including a a 5g unit, a 20g unit, a 50g unit and a 1000g unit. Our DHM (Dihydromyricetin) Powder is of the highest quality.
Store securely in a dry cool location away from direct sunlight. Keep out of reach of children and pets. Do not take this or any other supplement, and instead consult doctor about use, if you are under the age of 18, pregnant or breastfeeding, taking prescription or OTC / nonprescription drugs, or if you have any known or suspected medical conditions. Do not use if product safety seal was damaged or missing upon receipt.
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Scientifically Tailored Ingredients

Dihydromyricetin (DHM), also known as Ampelopsin, is a naturally occurring flavonoid found in a wide variety of plants across the world. Plants with high levels of dihydromyricetin are commonly incorporated into traditional Chinese medicine (TCM) and traditional Japanese medicine (Kampo).

– Supports a healthy liver
– Promotes recovery
– Antioxidant

Silva, J., Yu, X., Moradian, R., Folk, C., Spatz, M.H., Kim, P., Bhatti, A.A., Davies, D.L. and Liang, J. (2020), Dihydromyricetin Protects the Liver via Changes in Lipid Metabolism and Enhanced Ethanol Metabolism. Alcohol Clin Exp Res, 44: 1046-1060. doi:10.1111/acer.14326.

Shen, Y., Lindemeyer, A. K., Gonzalez, C., Shao, X. M., Spigelman, I., Olsen, R. W., & Liang, J. (2012). Dihydromyricetin as a novel anti-alcohol intoxication medication. The Journal of neuroscience: the official journal of the Society for Neuroscience, 32(1), 390–401.

Ren, Z., Yan, P., Zhu, L., Yang, H., Zhao, Y., Kirby, B. P., Waddington, J. L., & Zhen, X. (2018). Dihydromyricetin exerts a rapid antidepressant-like effect in association with the enhancement of BDNF expression and inhibition of neuroinflammation. Psychopharmacology, 235(1), 233–244.

Li, H., Li, Q., Liu, Z., Yang, K., Chen, Z., Cheng, Q., & Wu, L. (2017). The Versatile Effects of Dihydromyricetin in Health. Evidence-based complementary and alternative medicine : eCAM, 2017, 1053617.