Dihydromyricetin – also known as DHM or Ampelopsin – is a relatively new supplement that occurs in a number of plant species and is used for anti-alcohol and liver-support benefits. Ampelopsin has the chemical formula C15H12O8 and a molecular weight of 320.253 g/mol.
Dihydromyricetin (DHM) Benefits and Uses
Dihydromyricetin (DHM) is taken by mouth for its antioxidant and general health-supporting benefits. It has long been used in Traditional Chinese Medicine (TCM) for a variety of health-supporting effects. More recently, modern scientific investigations have uncovered several modes of action that corroborate DHM’s support of general health including modulation of inflammatory cytokines, modulation of autophagy, modulation of metabolic responses, neuroprotective properties and support of mitochondrial health.
Recent research studies have also revealed several important mechanisms of action relating to DHM’s potential ability to protect the liver and reduce unwanted unpleasant feelings from alcohol use:
- DHM triggers the production of the enzymes alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH)
- DHM appears to improve the efficacy of both ADH and ALDH
- DHM helps to reduce fatty acid accumulation in the liver
- DHM reduced the expression of inflammation markers in the liver, including IL-1β, NF-κB, and TNF-α.
DHM is known by a number of alternative names including:
- Ampelopsin
- (2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
- Ampelopsis
- Hovenia dulcis flavonoid extract
- Dihydromyricetin
Scientific Consensus
DHM is likely safe when taken by mouth. It is taken commonly to help ameliorate unwanted unpleasant feelings from alcohol use and protect the liver. As an oral supplement, the recommended serving size of Dihydromyricetin is 400 mg. Take 1-2 servings up to twice per day.
There is still a need for further research into the significance of DHM’s benefits and adverse effects. Nevertheless, Dihydromycetin appears safe for use at the recommended serving size, with only mild side effects very rarely being reported. There is insufficient research to support the use of DHM (Ampelopsin) supplementation during pregnancy and breastfeeding.
