Baicalein (Skullcap Extract) Powder

Unit Size

Want a discount? Become a member!


Baicalein (5,6,7 trihydroxyflavone) is the primary active component from the Baikal Skullcap (Blue Skullcap) and is the aglycone derivative of Baicalin. It has the chemical formula C15H10O5 and a molecular mass of 270,240 g/mol.

Baicalein Benefits and Uses

This compound has 2-3 times better efficacy (in terms of absorption) than Baicalin and is best known for its antioxidant and circulatory system-supporting effects. Anecdotally, some users report mild stress-relief and relaxing effects when using this supplement.

Baicalein is known by a number of alternative names, including:

  • Scutellaria baicalensis
  • Huang qin
  • Scutellariae radix
  • Baikal Skullcap
  • Blue Skullcap
  • Golden Root
  • 5,6,7-Trihydroxy-2-phenyl-chromen-4-one
  • 5,6,7-Trihydroxyflavone

Scientific Consensus

Baicalein is an alkaloid compound extracted from the Skullcap plant with stronger efficacy than Baicalin. It is considered likely safe for use at the suggested serving size. Baicalein may interact with some medications, including alcohol. Do not exceed the recommended serving size.

Warning: There is not enough research about the safety of Baicalein for pregnant and breastfeeding women. Do not use this supplement if you have any underlying medical conditions – especially bleeding disorders, diabetes, hormone-sensitive conditions, or low blood pressure. Avoid use for up to 2 weeks before surgery.

Read More
The statements on this page have not been evaluated by the FDA. The products on this page are not intended to diagnose, treat, cure, or prevent any disease.
December 18, 2023
Baicalein (Skullcap Extract) Powder

Imo, LM has one of the finest baicalein products on the market today. It's hard to find the level of quality that this offers. It can be a bit on the pricey side but is worth it.

February 19, 2023
Baicalein (Skullcap Extract) Powder

Has noted differences when compared to baicalin. Highly recommended.

October 2, 2022
Baicalein (Skullcap Extract) Powder

It works great and even though it expensive it works in controlling my stress and eye pressure

February 23, 2021
Baicalein (Skullcap Extract) Powder

I took this with the Cistanche Deserticola Extract and felt my muscles relax and become less tense. Will have to do some more testing but so far so good.

As a dietary supplement, take 1-2 servings up to 3 times per day. Please start with the lowest suggested single serving quantity to assess response.

Supplement Facts

Serving size: 250mg
Servings per container:
Amount per serving: % DV

BaicaleinScutellaria baicalensis extract (root) [std. to 98% Baicalein (248 mg)]

LiftMode offers a variety of unit sizes of HPLC-tested Baicalein (Skullcap Extract) Powder, including a a 5g unit, a 10g unit and a 20g unit. Our Baicalein (Skullcap Extract) Powder is of the highest quality.
Store securely in a dry cool location away from direct sunlight. Keep out of reach of children and pets. Do not take this or any other supplement, and instead consult doctor about use, if you are under the age of 18, pregnant or breastfeeding, taking prescription or OTC / nonprescription drugs, or if you have any known or suspected medical conditions. Do not use if product safety seal was damaged or missing upon receipt.
Read More
Free from additives and fillers
Gluten Free
HPLC Lab tested
Money back guarantee
Science backed

Scientifically Tailored Ingredients

Baicalein is the primary active component from the Blue Skullcap plant (also known as Baikal Skullcap). This powerful phytochemical is known to act on GABA receptors to promote relaxation and relieve stress. Baicalein also acts as a strong antioxidant supplement and helps to promote a healthy circulatory system.

• Calming and Stress-Reducing
• Antioxidant and Immune Support
• 5 – 10x Bioavailability Compared to Baicalin

Bochoráková, H., Paulová, H., Slanina, J., Musil, P., Táborská, E. (2003). Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Phytother Res, 17(6):640-4.

Gao, Z., Huang, K., Yang, X., Xu, H. (1999). Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochim Biophys Acta, 1472(3):643-50.

Zhao, Q., Chen, X.Y., Martin C. (2016). Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants. Sci Bull (Beijing). 2016;61(18):1391-1398.

Wang, H., Hui, K.M., Chen, Y., Xu, S., Wong, J.T., Xue, H. (2002). Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to the benzodiazepine site of GABA(A) receptor complex. Planta Med, 68(12):1059-62.

Guo, M., Zhang, N., Li, D., Liang, D., Liu, Z., Li, F., Fu, Y., Cao, Y., Deng, X., Yang, Z. (2013). Baicalin plays an anti-inflammatory role through reducing nuclear factor-κB and p38 phosphorylation in S. aureus-induced mastitis. Int Immunopharmacol, 16(2):125-30.