Serenity without sedation.

A research-driven supplement to soften life’s edges, tame tension, and promote meditative clarity: BaiCalm is calm you can feel.

Containing an HPLC-verified, synergized stack of bioactive, GABAergic, tranquility-promoting plant extracts, Baicalm is an ‘Advanced Calm Complex’: masterfully formulated for superior bioavailability, delivering noticeable calm, and a heightened sense of well-being.

How it Works: Gabaergic compounds and nervous system regulation

The inhibitory signaling of GABA (γ-Aminobutyric acid) via binding and activation of GABA receptors is a key messaging system a healthy central nervous system utilizes to reduce neuronal excitability and regulate emotions such as fear, panic, or intense stress. Developed via our three pillar methodology, the BaiCalm formula starts with a research-driven, synergized stack of potent, natural GABAergic compounds.

Pillar 1: GABAergic Synergy – 3 Calming Plant Extracts

> Scutellaria Baicalensis Extract [Std. to ≥98% Baicalein]

Baicalein (5,6,7-trihydroxyflavone) is a potent flavonoid from Skullcap (S. Baicalensis), with a long history of use in Traditional Chinese Medicine. 2-3x more bioavailable than baicalin, a wealth of studies have asserted strong GABAergic activity of baicalein via modulation of the brain’s benzodiazepine site of the GABA-A receptors. This subtle but noticeable downshift of neuronal response to ‘fight or flight’ supports serenity without sedation – so you can wind down without tuning out.

Not only a long-term LiftMode favorite for calming nerves, baicalein is a potent antioxidant and has been extensively researched for a myriad of other ways in which it can promote wellbeing – including activities as a neuroprotective, a promoter of circulatory health, and supporter of an upbeat and resilient mood – each enabled by gentle downregulation of cytokine signaling throughout the brain and body.

> Magnolia Bark Extract [Std. to ≥95% Honokiol & Magnolol]

Baicalm’s Magnolia Bark Extract (M. Officianalis), favored in TCM as a soothing relaxant, contains a ≥95% concentration of powerful bioactive neolignan constituents magnolol and honokiol. Synergizing with baicalein, these neuroprotective compounds have both been shown to enhance GABAergic neurotransmission, binding to and positively modulating GABA-A receptors.

Research continues to explore other positive effects of magnolol and honokiol, beyond their impact on mood-regulating serotonin receptors and stress-related catecholamines. Magnolia bark extract continues to be a popular natural remedy for not only calming, but also as a supplement to enhance mood, reduce stress and support an overall sense of reassurance and wellbeing.

At LiftMode, we call it “the BaiCalm glow”.

> Sinomenium Accutum Extract [Std. to ≥98% Sinomenine HCL]

Extracts of the plant Sinomenium acutum have a long history of use in Japan, China and Korea as traditional medicine for stabilizing mood, easing discomfort and soothing various aches and pains. Only recently have researchers begun to explore this natural extract’s primary alkaloid (Sinomenine) and its relaxing and relieving properties, with animal trial results attributing these effects in part due to GABAergic system modulation via interaction with GABA-A receptors.

While the use of sinomenine in higher doses has been explored as a potential sleep aid, Our Baicalm serving is formulated to deliver the perfect amount for daily tranquility, stress reduction, and comfort.

Pillar 2: Wakeful Rest – Meditative Focus

> L-Theanine [Std. to ≥99% pure]

Present in small amounts in tea and mushrooms, L-theanine is credited for the sense of relaxed contentment and clarity of thought after drinking green tea.

In recent years, studies have continued to evidence the calm-promoting and focus-inducing properties of this phytochemical. Research using electroencephalograph (EEG) found that consumption of L-theanine significantly increases alpha wave brain activity, a wave frequency observed in the brain during meditation and in states of wakeful rest. One serving of BaiCalm contains the L-Theanine content of about 12 strong cups of green tea.

Pillar 3: Superior Bioavailability – An Advanced Calm Complex

> Curcumin [Standardized to ≥95% curcuminoid]
> Black Pepper Fruit Extract [≥95% Piperine]

Our R&D team set out with a goal to deliver the most effective baicalein complex on the market.

Key in this effort was the addition of synergistic ingredients to enhance its GABAergic properties, but we also needed to address some longstanding challenges with standalone baicalein extracts: delayed onset, and limited absorption due to low GI solubility and stability.

After a long developmental process, and the carefully balanced addition of curcumin and piperine, our BaiCalm complex contains the perfect delivery system, painstakingly formulated for ultimate bioavailability. Piperine is well known for its positive impact on metabolism, and its ability to significantly improve the absorption and uptake of many dietary supplements. In the specific case of curcumin, piperine increases bioavailability by up to 2000%. When paired with baicalein, research found curcumin to be even superior to piperine in inhibiting glucuronidation in the lower intestine, resulting in superior baicalein absorption.

It is the effect of this three-step synergy (Piperine > Curcumin > Baicalein) we call our “Advanced Calm Complex”.

More than just an absorption aid, curcumin is also a potent antioxidant, neuroprotective, and a safe daily supplement for a myriad of health benefits. With a low molecular weight enabling passage through the blood-brain barrier, curcumin is capable of interacting with neurotransmitters such as serotonin, making it the subject of extensive research into its potential as a daily supplement to support calm and brighten one’s mood.

A safe natural polyphenol extracted from turmeric root, curcumin maximizes synergy, and is the finishing phytochemical touch to enhance relaxation and promote a palpable sense of well-being

The LiftMode Sleep Stack is a capsule formula containing four ingredients that aimed at promoting healthy sleep and relaxation. It is best taken about 2 hours prior to sleep and it may help support better sleep cycles.

LiftMode Sleep Caps Benefits and Uses

The LiftMode Sleep Stack capsules have been developed in such a way that you won’t need to worry about a large serving size. A single capsule has enough active components to greatly assist with sleep.

A powerful combination of four natural compounds known to help promote healthy rest and relaxation. It is best taken prior to sleep, but can also be used throughout the day to promote calm and relaxation.

Note: Due to country specific legal and regulatory restrictions, we do not ship Melatonin or Melatonin containing products to a number of countries, including the UK, member countries of the EU, Japan, Australia, and Canada.

Scientific Consensus

No clinical studies have been performed on this supplement stack. The potential benefits listed are anecdotal. This supplement stack contains ingredients that are well-known to produce relaxing effects, but the significance of their combination has not yet been researched.

DO NOT EXCEED THE RECOMMENDED SERVING SIZE. Use with caution. Do not use if pregnant or breastfeeding.

Warning: The ingredients in this supplement stack may interact with a variety of medications. This stack contains Levo-Tetrohydropalmatine, which may be dangerous to your health at servings greater than 120 mg. Do not exceed the serving suggestion.

Kanna Extract capsules are a powerful mood-support supplement derived from the African succulent, Sceletium tortusum. It grows naturally in the Namaqualand region of South Africa and has been used for millennia by the Khoisan bushmen. Our extract contains very high concentrations of the alkaloids Mesembrine and Mesembrenone.

Kanna Extract Capsules Benefits and Uses

Anecdotally, Kanna capsules are said to produce tranquil yet improved states of mood, while acting as a mild stress-reducing supplement. Some people use Kanna extract capsules for cognition. Research has indicated that Kanna powder acts as an inhibitor of the PDE4 enzyme.

Kanna extract contains several important alkaloids. For purposes of taxonomy, scientists have given all of the Kanna-derived alkaloids the prefix: “mesembr-”. The most important alkaloids include:

• Mesembrine
• Mesembrenone
• Mesembrenol
• Mesembranol

Kanna Extract capsules are known by a number of alternative names, including:

• Sceletium Tortuosum
• Channa
• Kougoed
• Mesmebrine
• Mesembrenone
• Mesembryanthemaceae
• S.tortuosum
• MT55
• Sceletium

Scientific Consensus

An extremely long history of use suggests that using the fermented plant is safe and effective, but does not provide sufficient proof. Further, very few studies have been conducted using a strong Kanna Extract capsules. More research is needed to fully understand the significance of the benefits and adverse effects of this supplement. There is not enough research about the safety of Kanna Extract capsules for pregnant and breastfeeding women.

One of a kind capsules, combining natural ingredients to provide mildly energizing physical and mental boost. MoodLift is the ideal supplement stack for those seeking a daily natural, caffeine free, boost to mood, energy and wellbeing. Seize the Day with Moodlift.

The 20 vitamins, minerals, nutrients, biochemical precursors, and plant extracts work in unison to produce a dynamic mood-enhancing, stress-reducing and gently energizing effect, and were developed using our Three Pillar methodology:

Pillar 1: Calming and Stress Reducing Plant Extracts

The first pillar contains a combination of five naturally occurring herbal extracts known to help to reduce feelings of stress, while providing a gentle calming and relaxing effect – mostly through effects on the GABAergic system.

Magnolol (Magnolia Bark Extract) (28 mg) is the active compound found in the bark of the Houpu magnolia plant and has relaxing (although not sedating) GABAergic activity with added health benefits.

Baicalein (Blue Skullcap Extract) (60mg) is one of active biochemical compounds found in the root of the native American plant, Scutellaria baicalensis and is used primarily for its antioxidant and anti-inflammatory properties, along with its calming, stress-reducing benefits.

Piperine (Black Pepper Extract) (6 mg) is a potent PGP and CYP enzyme inhibitor that temporarily inhibits Glucuronidation (the ‘tagging’ of foreign substances by immune cells), allowing improved bioavailability of biochemical compounds; also known for its mood-supporting effects.

Sinomenium acutum Extract (36 mg) has been used traditionally for its neuroprotective, anti-inflammatory and analgesic properties; also for its PGP inhibitor effects to increase bioavailability of other compounds.

Gotu Kola Extract (28 mg) is an adaptogen and natural Nootropic, well-known for its potent relaxing effects. The primary active components of Gotu Kola are triterpenoid saponins Asiaticoside, Asiaticoside B, and Madecassoside, which have strong mood-enhancing, relaxing, and anti-inflammatory effects.

Pillar 2: Synergistic Energizing Vitamins, Nutrients, and Plant Extracts 

The second pillar of MoodLift consists of a combination of 6 herbal extracts and vitamins, uniquely combined in the perfect synergistic ratio to provide a gentle energizing effect, without a crash afterwards.

Vitamin B12 (600 mg) is a water soluble vitamin that plays an essential role in the production of red blood cells (essential for optimal energy levels), immune function and improved memory. It, along with vitamin B6 and B1, is essential for monoamine neurotransmitter production.

Vitamin B6 (as Pyridoxine HCl) (3 mg) is a water soluble vitamin that plays an important role specifically in protein metabolism, production of healthy blood cells for energy as well as supporting healthy cognition and mood.

Benfotiamine (28 mg) is a synthetic precursor of Vitamin B1, also known as Thiamine. Thiamine plays an important role in helping our bodies convert food into energy, and is recognised for its beneficial effects in supporting nerve, muscle, and heart function.

Folate (0.6 mg) is a form of vitamin B9 and an essential component of DNA repair. It is also used to help synthesize red blood cells and convert carbohydrates into cellular energy.

7,8-DHF (Dihydroxyflavone) (36 mg) is a naturally-occurring compound, believed to support learning and reduce mental fatigue by directly binding to the tropomyosin-related kinase B (TrkB) and enhancing TrkB expression, thereby improving the rate at which new synapses are formed.

Ginseng (Panax ginseng) (56 mg) is a herbal physical and cognitive adaptogen that has been used in Traditional Chinese Medicine (TCM) for centuries. It contains natural powerful ginsenosides that are responsible for this supplement’s beneficial effects on physical energy levels and mental focus.

Pillar 3: Natural Extracts and Biochemical Precursors for Catecholamine Care

The Third Pillar consists of a combination of natural extracts and biochemical precursors that work collectively to gently enhance mood: by activating the catecholamine system and/or improving the brain’s natural production of serotonin – an important monoamine neurotransmitter known widely for its effects on mood. The catecholamine system supports the body’s response to stress and is regulated by epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine.

Barley Malt Extract (18 mg) is a dietary supplement that is related to tyramine and contains high concentrations of Hordenine HCI (standardized to 98%). Hordenine HCl is a gentle, naturally-occurring MAOI that boosts catecholamine levels to support mental and physical energy and a positive mood.

Rhodiola Rosea (56 mg) is used for its perceived effects in increases our body’s resistance to stress. It is a physical and cognitive adaptogen that is traditionally used to reduce fatigue, while also supporting catecholamine levels.

Triacetyluridine (TAU) (18 mg) is a biochemical precursor to the nucleoside Uridine. Uridine plays an important role in cellular signalling, specifically in our brains. It is best-known for its positive effects on cognitive function, memory and mood, and helps support healthy dopamine and CDP-Choline levels.

Oroxylin A (18 mg) is one of the main flavonoid compounds found in the root of the Oroxylin indicum plant and is known primarily for its antioxidant and anti-inflammatory properties. It is also known to boost levels of catecholamine transmitters like dopamine and norepinephrine. Oroxylin A has demonstrated therapeutic effects in improving stress, sleep quality and memory by stimulating gamma-aminobutyric acid (GABA-A) receptors.

Citicoline (CDP-Choline) (28 mg) is a naturally-occurring compound produced through several biochemical systems in the human body. It is metabolized into Choline and Cytidine, which are then used to resynthesize CDP-Choline in the brain. CDP-Choline is best-known as a cognitive support supplement to help promote health cognitive performance and memory. Studies have shown that it may be effective in supporting focus, attention and learning.

Pillar 4: Potent Mood Enhancing Biochemical Compounds

The Fourth Pillar of MoodLift is comprised of four plant extracts and biochemical precursors that were carefully selected for their capacity to work in unison and provide a gentle serotonin boosting effect. Serotonin has long been known for its beneficial effects on supporting a positive mood and outlook.

Kanna (Sceletium tortuosum) (28 mg) is a well-known and increasingly popular plant extract used for its effects in producing a relaxed yet cheerful mood. Often used to improve sociability, Kanna works by boosting levels of the neurotransmitters Serotonin and Norepinephrine.

Peony Root extract (38 mg) also known as Paeonia lactiflora Pall, is a novel plant extract that supports a positive mood by reducing the expression of serotonin transporter (SERT): a protein that binds to serotonin so it can be broken down and recycled. Inhibiting SERT prevents this process, thus increasing serotonin levels to produce a temporary mood enhancing effect.

5-HTP (28 mg) is an amino acid precursor to the important neurotransmitter serotonin. It is also known to support a positive mood and promote healthy sleep.

THH (Tetrahydroharmine) (18 mg) is a component of B.caapi, used for its effects in regulating motivation and overall mood. THH has a half-life of 10 hours and acts as an inhibitor of a specific enzyme called monoamine oxidase A (MAO-A), which regulates the functioning of two important neurotransmitters dopamine and serotonin. It is also unique in potentially being able to support adult neurogenesis.

This product contains 60 delayed-release capsules of MoodLift in a high quality white, reclosable plastic capsule jar with an integrated Safety Seal and Shrinkband. A single serving is 2 capsules.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Do not take this supplement if you are under the age of 18, pregnant or nursing, or have a known or suspected medical condition. Do not combine with prescription antidepressants or MAOIs. Do not take within 3 hours of any prescription medications.